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Canal Letter
Writer at Silicon Canals

Canal Letter

Contributor

Canal Letter is Silicon Canals' weekly briefing on the global innovation ecosystems we cover, with particular attention to European startup activity. Articles under this column are produced by our editorial team under the direction of the Chief Publisher.

Technology

Booking.com still runs on the internal A/B testing framework its engineers wrote in Amsterdam in the mid-2000s, with no major rewrite since, and at any given moment it is running more than 1,000 live experiments on the same booking page you’re looking at

Booking.com runs more than 1,000 concurrent experiments on its production booking flow through an in-house framework its Amsterdam engineers built in the late 2000s — a foundational piece of software that has been extended continuously but never rewritten. The case reveals how the most powerful systems in modern e-commerce are often the oldest.

Technology

A 35-year-old founder’s perfect biomarkers missed a fist-sized tumour, and what Claude caught on his final PET scan — just as his oncologist began discussing radiotherapy near his heart — is the real story about AI in medicine

A 35-year-old founder with near-perfect biomarkers, four years of optimised bloodwork, and a Whoop band that tracked his sleep against an Oura ring discovered a tumour the size of a fist behind his sternum — not through any of his tracking, but by accident.

Technology

ASML in Veldhoven ships each EUV lithography machine in roughly 250 crates aboard multiple Boeing 747s, the mirrors inside are polished so finely that scaled to the size of Germany the largest bump would be under a millimetre tall, and every advanced chip in every iPhone on Earth passes through one of these machines before it reaches a pocket

ASML insists it can account for every one of the 314 EUV lithography machines it has ever shipped — and that none of them, nor any component designed for one, has reached China. US Commerce Secretary Howard Lutnick says otherwise. The fight reveals just how concentrated the world's chip supply chain has become.

Business

Stripe’s payment infrastructure was built in a Palo Alto apartment by two Irish brothers from Limerick who, before they turned 25, had convinced Peter Thiel and Elon Musk to back them, and the company’s annual payment volume now exceeds the entire GDP of Ireland by more than three times

Stripe processed $1.4 trillion in payment volume in 2024 — roughly 2.6 times Ireland's GDP — and the founders built the first version in a Palo Alto apartment before either turned 25.